Anti-Human SENP1 Polyclonal Antibody (HP578014)

Name: Anti-Human SENP1 Polyclonal Antibody
Brand: abinScience
SKU: HP578014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HP578014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SENP1 (Glu422-Leu644).

Target

Sentrin/SUMO-specific protease SENP1, SENP1, Sentrin-specific protease 1

Purification

Purified by antigen affinity column.

Accession

Q9P0U3

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Sentrin-specific protease 1 (SENP1) is a ~73 kDa protein. Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity.

1. Gong, L. et al. (2000) The Journal of biological chemistry 275, 3355-9. PMID: 10652325

2. Cheng, J. et al. (2004) Molecular and cellular biology 24, 6021-8. PMID: 15199155

3. Xu, Z. et al. (2005) The Biochemical journal 386, 325-30. PMID: 15487983

4. Kim, YH. et al. (2005) FEBS letters 579, 6272-8. PMID: 16253240

5. Shen, LN. et al. (2006) The Biochemical journal 397, 279-88. PMID: 16553580

6. Hong, Y. et al. (2011) PloS one 6, e23046. PMID: 21829689

7. Cong, L. et al. (2011) The Journal of biological chemistry 286, 43793-43808. PMID: 21965678

8. Li, S. et al. (2013) Oncogene 32, 4883-91. PMID: 23160374

9. Bi, H. et al. (2014) Molecular biology of the cell 25, 2499-508. PMID: 24943844

10. Park, JH. et al. (2014) Nature communications 5, 5483. PMID: 25406032

Note

For research use only.

Images

References

Datasheet

Anti-Human SENP1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-Human SENP1 Polyclonal Antibody (HP578014)

Overview

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Datasheet

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