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Anti-Human NTB-A/SLAMF6 Polyclonal Antibody (HV585014)

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Overview
Catalog No.HV585014
Description
Anti-Human SLAMF6 Polyclonal Antibody (HV585014) is a rabbit polyclonal antibody detecting SLAM family member 6; Activating NK receptor; NK-T-B-antigen; NTB-A; CD352; SLAMF6; KALI; UNQ6123/PRO20080 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant human SLAMF6 (Gln22-Met226).
Target SLAM family member 6; Activating NK receptor; NK-T-B-antigen; NTB-A; CD352; SLAMF6; KALI; UNQ6123/PRO20080
Endotoxin level Please contact with the lab for this information.
Purity >95% as determined by SDS-PAGE.
Purification Purified by antigen affinity column.
Accession Q96DU3
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

SLAM family member 6 (SLAMF6) is a ~37 kDa protein. Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. Positive signaling in NK cells implicates phosphorylation of VAV1.

1. Bottino, C. et al. (2001) The Journal of experimental medicine 194, 235-46. PMID: 11489943
2. Eissmann, P. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 177, 3170-7. PMID: 16920955
3. Chatterjee, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 188, 1206-12. PMID: 22184727
4. Chatterjee, M. et al. (2012) The Journal of biological chemistry 287, 38168-77. PMID: 22989874
Note For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
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