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Anti-Human SPHK2 Polyclonal Antibody (HP741014)

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Overview
Catalog No.HP741014
Description
Anti-Human SPHK2 Polyclonal Antibody (HP741014) is a rabbit polyclonal antibody detecting SPHK2 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human SPHK2 (Gly170-His370).
Target SK2, Sphingosine kinase 2, SPHK2, SK 2, SPK 2
Purification Purified by antigen affinity column.
Accession Q9NRA0
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Sphingosine kinase 2 (SPHK2) is a ~69 kDa protein. Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides. In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis. In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration.

1. Igarashi, N. et al. (2003) The Journal of biological chemistry 278, 46832-9. PMID: 12954646
2. Don, AS. et al. (2009) Biochemical and biophysical research communications 380, 87-92. PMID: 19168031
3. Maceyka, M. et al. (2005) The Journal of biological chemistry 280, 37118-29. PMID: 16118219
4. Strub, GM. et al. (2011) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 25, 600-12. PMID: 20959514
5. Hait, NC. et al. (2009) Science (New York, N.Y.) 325, 1254-7. PMID: 19729656
6. Okada, T. et al. (2005) The Journal of biological chemistry 280, 36318-25. PMID: 16103110
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human SPHK2 Polyclonal Antibody

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