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Anti-Human SRP68 Polyclonal Antibody (HP400014)

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Overview
Catalog No.HP400014
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human SRP68 (Met293-Gln540).
Target Signal recognition particle 68 kDa protein, Signal recognition particle subunit SRP68, SRP68
Purification Purified by antigen affinity column.
Accession Q9UHB9
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Signal recognition particle subunit SRP68 is a ~70 kDa protein. Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER. The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER. Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently. The SRP complex possibly participates in the elongation arrest function.

1. Lee, JH. et al. (2021) Science advances 7. PMID: 34020957
2. Iakhiaeva, E. et al. (2006) Protein science : a publication of the Protein Society 15, 1290-302. PMID: 16672232
3. Becker, MM. et al. (2017) Nucleic acids research 45, 470-481. PMID: 27899666
Note For research use only.
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Formula
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Anti-Human SRP68 Polyclonal Antibody

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