

| Catalog No. | HT479014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human SSNA1 (Leu15-Arg98). | ||||||||
| Target | SSNA1, NA14, Sjoegren syndrome nuclear autoantigen 1, Nuclear autoantigen of 14 kDa | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | O43805 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Microtubule nucleation factor SSNA1 is a ~13 kDa protein. Microtubule-binding protein which stabilizes dynamic microtubules by slowing growth and shrinkage at both plus and minus ends and serves as a sensor of microtubule damage, protecting microtubules from the microtubule-severing enzyme SPAST. Induces microtubule branching which is mediated by the formation of long SSNA1 fibrils which guide microtubule protofilaments to split apart from the mother microtubule and form daughter microtubules. Plays a role in axon outgrowth and branching. Required for cell division. 1. Lawrence, EJ. et al. (2021) eLife 10. PMID: 34970964 2. Goyal, U. et al. (2014) PloS one 9, e112428. PMID: 25390646 | ||||||||
| Note | For research use only. |



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