Anti-Human STEAP4 Polyclonal Antibody (HP364014)

Name: Anti-Human STEAP4 Polyclonal Antibody
Brand: abinScience
SKU: HP364014
Price: 168 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HP364014

Description

Anti-Human STEAP4 Polyclonal Antibody (HP364014) is a rabbit polyclonal antibody detecting STEAP4 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human STEAP4 (Thr21-Gln195).

Target

STEAP4, STAMP2, Tumor necrosis factor, alpha-induced protein 9, Metalloreductase STEAP4, TNFAIP9, Six-transmembrane epithelial antigen of prostate 4, SixTransMembrane protein of prostate 2

Purification

Purified by antigen affinity column.

Accession

Q687X5

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Metalloreductase STEAP4 is a ~51 kDa protein. Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate. Can also reduce Cu(2+) to Cu(1+). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses. Associated with obesity and insulin-resistance.

1. Oosterheert, W. et al. (2018) Nature communications 9, 4337. PMID: 30337524

2. Arner, P. et al. (2008) The Journal of clinical endocrinology and metabolism 93, 2249-54. PMID: 18381574

3. Zhang, CM. et al. (2008) Acta pharmacologica Sinica 29, 587-92. PMID: 18430367

4. Inoue, A. et al. (2009) Arthritis research & therapy 11, R118. PMID: 19660107

5. Tamura, T. et al. (2009) International journal of molecular medicine 24, 599-604. PMID: 19787193

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Human STEAP4 polyclonal antibody at 1ug/mL on recombinant Human STEAP4 (Catalog No. HP364012).

References

Datasheet