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Anti-Human TNF-alpha Recombinant Antibody (SAA2235), Biotin (HF879313)

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Overview
Catalog No.HF879313
Description
Anti-Human TNF-alpha Recombinant Antibody (SAA2235), Biotin (HF879313) is a rabbit monoclonal antibody detecting TNF-alpha in ELISA. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Biotin Conjugated — Ready for direct detection without secondary antibody.
Species reactivityHuman
ApplicationsELISA
Host speciesRabbit
ClonalityMonoclonal
IsotypeIgG
Clone IDSAA2235
ConjugationBiotin
Target C-domain 1, C-domain 2, Cachectin, ICD1, ICD2, Intracellular domain 1, Intracellular domain 2, N-terminal fragment, NTF, TNF, TNF-a, TNF-alpha, TNFA, TNFSF2, Tumor necrosis factor, Tumor necrosis factor ligand superfamily member 2, Tumor necrosis factor, membrane form, Tumor necrosis factor, soluble form
Endotoxin level Please contact with the lab for this information.
Purity >90% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession P01375
RRID Anti-Human TNFa/TNF-alpha Antibody (SAA2235), Biotin (abinScience Cat# HF879313, RRID:AB_3729838)
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage Store at 4°C for 12 months. Protect from light. Do not freeze.
Background

Tumor necrosis factor (TNFA) is a ~25 kDa protein. Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective.

1. Nie, H. et al. (2013) Nature medicine 19, 322-8. PMID: 23396208
2. Friedmann, E. et al. (2006) Nature cell biology 8, 843-8. PMID: 16829952
3. Jinesh G, G. et al. (2012) Journal of leukocyte biology 92, 233-44. PMID: 22517918
4. Nakahara, H. et al. (2003) Arthritis and rheumatism 48, 1521-9. PMID: 12794819
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human TNF-alpha Recombinant Antibody (SAA2235), Biotin

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