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Anti-Human TRIM37 Polyclonal Antibody (HF616014)

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Overview
Catalog No.HF616014
Description
Anti-Human TRIM37 Polyclonal Antibody (HF616014) is a rabbit polyclonal antibody detecting TRIM37 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human TRIM37 (Ser275-Ser405).
Target E3 ubiquitin-protein ligase TRIM37, 2.3.2.27, Mulibrey nanism protein, RING-type E3 ubiquitin transferase TRIM37, Tripartite motif-containing protein 37, TRIM37, KIAA0898, MUL, POB1
Purification Purified by antigen affinity column.
Accession O94972
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

E3 ubiquitin-protein ligase TRIM37 is a ~107 kDa protein. E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication. Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes. Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome. Has anti-HIV activity.

1. Kallijärvi, J. et al. (2005) Experimental cell research 308, 146-55. PMID: 15885686
2. Balestra, FR. et al. (2013) Developmental cell 25, 555-71. PMID: 23769972
3. Bhatnagar, S. et al. (2014) Nature 516, 116-20. PMID: 25470042
4. Wang, W. et al. (2017) The Journal of cell biology 216, 2843-2858. PMID: 28724525
5. Tabah, AA. et al. (2014) The Journal of general virology 95, 960-967. PMID: 24317724
Note For research use only.
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Datasheet
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Formula
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Anti-Human TRIM37 Polyclonal Antibody

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