Anti-Human TRPV1 Recombinant Antibody (SAA1705) (HV711013)

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Overview

Catalog No.

HV711013

Description

Anti-Human TRPV1 Antibody (SAA1705) [SAA1705] (HV711013) is a mouse monoclonal antibody detecting TrpV1 in ELISA. Suitable for Human.

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1705

Clonality

Monoclonal

Target

VR1, Vanilloid receptor 1, Transient receptor potential cation channel subfamily V member 1, Capsaicin receptor, Osm-9-like TRP channel 1, TrpV1, TRPV1, OTRPC1

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q8NER1

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a ~94 kDa protein. Non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activated by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius.

1. Hayes, P. et al. (2000) Pain 88, 205-215. PMID: 11050376

2. Cortright, DN. et al. (2001) Biochemical and biophysical research communications 281, 1183-9. PMID: 11243859

3. McIntyre, P. et al. (2001) British journal of pharmacology 132, 1084-94. PMID: 11226139

4. Smith, GD. et al. (2002) Nature 418, 186-90. PMID: 12077606

5. Neuberger, A. et al. (2023) Nature communications 14, 2451. PMID: 37117175

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human TRPV1 Antibody (SAA1705)

References

Datasheet

Anti-Human TRPV1 Recombinant Antibody (SAA1705).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human TRPV1 Recombinant Antibody (SAA1705) (HV711013)

Overview

Images

References

Datasheet

SDS

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