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Anti-Human TSC22D3 Polyclonal Antibody (HV509014)

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Overview
Catalog No.HV509014
Description
Anti-Human TSC22D3 Polyclonal Antibody (HV509014) is a rabbit polyclonal antibody detecting TSC22D3 in ELISA, IHC, WB. Suitable for Rattus norvegicus, Macaca fascicularis, Mus musculus, Human, and Sus scrofa.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human TSC22D3 (Met1-Val134).
Target TSC22D3
Purification Purified by antigen affinity column.
Accession Q99576
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate NamesTSC22 domain family protein 3, DSIP-immunoreactive peptide, Protein DIP, hDIP, Delta sleep-inducing peptide immunoreactor, Glucocorticoid-induced leucine zipper protein, GILZ, TSC-22-like protein, TSC-22-related protein, TSC-22R, TSC22D3, DSIPI, GILZ
Background

TSC22 domain family protein 3 (TSC22D3) is a ~14 kDa protein. Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities. In vitro, suppresses AP-1 transcription factor complex DNA-binding activities.

1. Asselin-Labat, ML. et al. (2004) Blood 104, 215-23. PMID: 15031210
2. Berrebi, D. et al. (2003) Blood 101, 729-38. PMID: 12393603
3. Ayroldi, E. et al. (2001) Blood 98, 743-53. PMID: 11468175
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human TSC22D3 Polyclonal Antibody

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