

| Catalog No. | HT497014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human TSPAN1 Polyclonal Antibody (HT497014) is a rabbit polyclonal antibody detecting TSPAN1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Species reactivity | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Clonality | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogen | E. coli - derived recombinant Human TSPAN1 (Tyr110-Asn211). | ||||||||
| Target | Tetraspanin-1, Tspan-1, Tetraspan NET-1, Tetraspanin TM4-C, TSPAN1 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | O60635 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Tetraspanin-1 (TSPAN1) is a ~26 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways. Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK. 1. Tian, J. et al. (2018) Molecular medicine reports 18, 3280-3288. PMID: 30066932 2. Yang, L. et al. (2018) Inflammation research : official journal of the European Histamine Research Society ... [et al.] 67, 951-964. PMID: 30291375 3. Nabokina, SM. et al. (2011) American journal of physiology. Gastrointestinal and liver physiology 301, G808-13. PMID: 21836059 | ||||||||
| Note | For research use only. |
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