Anti-Human UGT2B7 Polyclonal Antibody (HB028014)

Name: Anti-Human UGT2B7 Polyclonal Antibody
Brand: abinScience
SKU: HB028014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HB028014

Description

Anti-Human UGT2B7 Polyclonal Antibody (HB028014) is a rabbit polyclonal antibody detecting UGT2B7 in ELISA, IHC, WB. Suitable for Dog, Human, Macaca fascicularis, and Macaca mulatta.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human UGT2B7 (Ala285-Asp451).

Target

UGTB2B9, UDPGTh-2, UDPGT 2B9, UDP-glucuronosyltransferase 2B7, 3, 4-catechol estrogen-specific UDPGT, UGT2B7, UDPGT 2B7, UDP-glucuronosyltransferase 2B9

Purification

Purified by antigen affinity column.

Accession

P16662

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

UDP-glucuronosyltransferase 2B7 (UGT2B7) is a ~60 kDa protein. UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens). Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption.

1. Samokyszyn, VM. et al. (2000) The Journal of biological chemistry 275, 6908-14. PMID: 10702251

2. Picard, N. et al. (2005) Drug metabolism and disposition: the biological fate of chemicals 33, 139-46. PMID: 15470161

3. Lépine, J. et al. (2004) The Journal of clinical endocrinology and metabolism 89, 5222-32. PMID: 15472229

4. Miley, MJ. et al. (2007) Journal of molecular biology 369, 498-511. PMID: 17442341

5. Alonen, A. et al. (2008) Biochemical pharmacology 76, 763-72. PMID: 18674515

6. Itäaho, K. et al. (2008) Drug metabolism and disposition: the biological fate of chemicals 36, 2307-15. PMID: 18719240

7. Sten, T. et al. (2009) Drug metabolism and disposition: the biological fate of chemicals 37, 417-23. PMID: 19022937

8. Sneitz, N. et al. (2013) Drug metabolism and disposition: the biological fate of chemicals 41, 582-91. PMID: 23288867

9. Perreault, M. et al. (2013) Drug metabolism and disposition: the biological fate of chemicals 41, 1616-20. PMID: 23756265

10. Kallionpää, RA. et al. (2015) The Journal of steroid biochemistry and molecular biology 154, 104-11. PMID: 26220143

Note

For research use only.

Images

References

Datasheet

Anti-Human UGT2B7 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human UGT2B7 Polyclonal Antibody (HB028014)

Overview

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References

Datasheet

SDS

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