Anti-Human VIPR1/VPAC1 Recombinant Antibody (23A11), APC (HB111137)

Name: Anti-Human VIPR1/VPAC1 Recombinant Antibody (23A11), APC
Brand: abinScience
SKU: HB111137
Price: 290 USD
Availability: InStock

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Overview

Catalog No.	HB111137
Species reactivity	Human
Applications	FCM, WB
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	23A11
Conjugation	APC
Clonality	Monoclonal
Target	VIP-R-1, PACAP-R2, VIPR1, PACAP-R-2, Pituitary adenylate cyclase-activating polypeptide type II receptor, PACAP type II receptor, VPAC1, Vasoactive intestinal polypeptide receptor 1
Endotoxin level	Please contact with the lab for this information.
Associated products	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), APC
Accession	P32241
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Vasoactive intestinal polypeptide receptor 1 (VIPR1/VPAC1) is a ~51 kDa protein. G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP38. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. 1. Xu, Y. et al. (2022) Nature communications 13, 2272. PMID: 35477937 2. Piper, SJ. et al. (2022) Nature communications 13, 7013. PMID: 36385145 3. Couvineau, A. et al. (1994) Biochemical and biophysical research communications 200, 769-76. PMID: 8179610
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human VIPR1/VPAC1 Recombinant Antibody (23A11), APC.pdf

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Anti-Human VIPR1/VPAC1 Recombinant Antibody (23A11), APC (HB111137)

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