Anti-Human VPS18 Polyclonal Antibody (HD666014)

Name: Anti-Human VPS18 Polyclonal Antibody
Brand: abinScience
SKU: HD666014
Price: 168 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HD666014

Description

Anti-Human VPS18 Polyclonal Antibody (HD666014) is a rabbit polyclonal antibody detecting VPS18. Suitable for Mouse and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human VPS18 (Glu40-Glu394).

Target

KIAA1475, VPS18, Vacuolar protein sorting-associated protein 18 homolog, hVPS18

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q9P253

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Vacuolar protein sorting-associated protein 18 homolog (VPS18) is a ~110 kDa protein. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes.

1. Kim, BY. et al. (2001) The Journal of biological chemistry 276, 29393-402. PMID: 11382755

2. Solinger, JA. et al. (2013) The FEBS journal 280, 2743-57. PMID: 23351085

3. Jiang, P. et al. (2014) Molecular biology of the cell 25, 1327-37. PMID: 24554770

4. Wartosch, L. et al. (2015) Traffic (Copenhagen, Denmark) 16, 727-42. PMID: 25783203

Note

For research use only

Images

References

Datasheet

Anti-Human VPS18 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human VPS18 Polyclonal Antibody (HD666014)

Overview

Images

References

Datasheet

SDS

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