Human VPS18 Recombinant Protein (N-His) (HD666012)

Name: Human VPS18 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD666012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD666012
Description	Recombinant Human VPS18 Protein, N-His (HD666012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q9P253
Protein length	Glu40-Glu394
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	KIAA1475, VPS18, Vacuolar protein sorting-associated protein 18 homolog, hVPS18
Background	Vacuolar protein sorting-associated protein 18 homolog is a ~110 kDa protein. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes. 1. Kim, BY. et al. (2001) The Journal of biological chemistry 276, 29393-402. PMID: 11382755 2. Solinger, JA. et al. (2013) The FEBS journal 280, 2743-57. PMID: 23351085 3. Jiang, P. et al. (2014) Molecular biology of the cell 25, 1327-37. PMID: 24554770 4. Wartosch, L. et al. (2015) Traffic (Copenhagen, Denmark) 16, 727-42. PMID: 25783203
Note	For research use only

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Human VPS18 Recombinant Protein (N-His).pdf

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Human VPS18 Recombinant Protein (N-His) (HD666012)

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