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Anti-Human YTHDF3 Polyclonal Antibody (HA146014)

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Overview
Catalog No.HA146014
Description
Anti-Human YTHDF3 Polyclonal Antibody (HA146014) is a rabbit polyclonal antibody detecting YTHDF3 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human YTHDF3 (Gly416-Glu572).
Target YTH domain-containing family protein 3, DF3, YTHDF3
Purification Purified by antigen affinity column.
Accession Q7Z739
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

YTH domain-containing family protein 3 (YTHDF3) is a ~63 kDa protein. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs.

1. Shi, H. et al. (2017) Cell research 27, 315-328. PMID: 28106072
2. Li, A. et al. (2017) Cell research 27, 444-447. PMID: 28106076
3. Yang, Y. et al. (2017) Cell research 27, 626-641. PMID: 28281539
4. Zaccara, S. et al. (2020) Cell 181, 1582-1595.e18. PMID: 32492408
5. Dominissini, D. et al. (2012) Nature 485, 201-6. PMID: 22575960
6. Wang, X. et al. (2014) Nature 505, 117-20. PMID: 24284625
7. Ries, RJ. et al. (2019) Nature 571, 424-428. PMID: 31292544
Note For research use only.
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Datasheet
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Formula
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Anti-Human YTHDF3 Polyclonal Antibody

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