Anti-Human ZNF410 Polyclonal Antibody (HP086014)

Name: Anti-Human ZNF410 Polyclonal Antibody
Brand: abinScience
SKU: HP086014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HP086014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ZNF410 (Arg76-Ser191).

Target

ZNF410, APA1, Another partner for ARF 1, Zinc finger protein 410, Zinc finger protein APA-1

Purification

Purified by antigen affinity column.

Accession

Q86VK4

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Zinc finger protein 410 (ZNF410) is a ~52 kDa protein. Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells. Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells. May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence. May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose. However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4.

1. Lan, X. et al. (2021) Molecular cell 81, 239-254.e8. PMID: 33301730

2. Vinjamur, DS. et al. (2021) Nature genetics 53, 719-728. PMID: 33859416

3. Benanti, JA. et al. (2002) Molecular and cellular biology 22, 7385-97. PMID: 12370286

4. Chen, Y. et al. (2018) Journal of cellular physiology 234, 606-618. PMID: 30078215

Note

For research use only.

Images

References

Datasheet

Anti-Human ZNF410 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human ZNF410 Polyclonal Antibody (HP086014)

Overview

Images

References

Datasheet

SDS

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