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Anti-Human ZNF445 Polyclonal Antibody (HD104014)

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Overview
Catalog No.HD104014
Description
Anti-Human ZNF445 Polyclonal Antibody (HD104014) is a rabbit polyclonal antibody detecting ZNF445. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human ZNF445 (Leu478-Glu925).
Target ZFP445, ZKSCAN15, ZNF168, ZNF445, Zinc finger protein 168, Zinc finger protein 445, Zinc finger protein with KRAB and SCAN domains 15
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P59923
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Zinc finger protein 445 (ZNF445) is a ~118 kDa protein. Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance.

1. Takahashi, N. et al. (2019) Genes & development 33, 49-54. PMID: 30602440
Note For research use only
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Anti-Human ZNF445 Polyclonal Antibody

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