Anti-IL11 Polyclonal Antibody (HB978014)

Name: Anti-IL11 Polyclonal Antibody
Brand: abinScience
SKU: HB978014
Price: 168 USD
Availability: InStock

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Spec:

50ug
100ug

Number:

Overview
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References
Datasheet
SDS

Overview

Catalog No.

HB978014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human IL11 (Asp34-Leu199).

Target

Adipogenesis inhibitory factor, AGIF, IL11, IL-11, Interleukin-11, Oprelvekin

Purification

Purified by antigen affinity column.

Accession

P20809

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'.

1. Paul, SR. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 7512-6. PMID: 2145578

2. Harmegnies, D. et al. (2003) The Biochemical journal 375, 23-32. PMID: 12919066

3. Lamertz, L. et al. (2018) Science signaling 11. PMID: 30279168

Note

For research use only.

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