Anti-Human IL-4 Polyclonal Antibody (HY457014)

Name: Anti-Human IL-4 Polyclonal Antibody
Brand: abinScience
SKU: HY457014
Price: 168 USD
Availability: InStock

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Overview
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Overview

Catalog No.

HY457014

Description

Anti-IL4 Polyclonal Antibody (HY457014) is a rabbit polyclonal antibody detecting IL4 in ELISA, IHC, WB. Suitable for Human, Cercocebus atys, Macaca fascicularis, Macaca mulatta, and Pan troglodytes.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human IL4 (Gly24-Ser153).

Target

Binetrakin, B-cell stimulatory factor 1, Pitrakinra, Lymphocyte stimulatory factor 1, IL-4, BSF-1, IL4, Interleukin-4

Purification

Purified by antigen affinity column.

Accession

P05112

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Interleukin-4 (IL4) is a ~17 kDa protein. Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1. Also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages.

1. Carr, C. et al. (1991) Biochemistry 30, 1515-23. PMID: 1993171

2. Yokota, T. et al. (1986) Proceedings of the National Academy of Sciences of the United States of America 83, 5894-8. PMID: 3016727

3. Delespesse, G. et al. (1989) Journal of immunology (Baltimore, Md. : 1950) 142, 134-8. PMID: 2521231

4. Hage, T. et al. (1999) Cell 97, 271-81. PMID: 10219247

5. Hülsmeyer, M. et al. (2001) Acta crystallographica. Section D, Biological crystallography 57, 1334-6. PMID: 11526337

6. LaPorte, SL. et al. (2008) Cell 132, 259-72. PMID: 18243101

7. Malabarba, MG. et al. (1995) The Journal of biological chemistry 270, 9630-7. PMID: 7721895

Note

For research use only.

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References

Datasheet