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Anti-Lassa virus/LASV Nucleoprotein Polyclonal Antibody (VK810034)

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Overview
Catalog No.VK810034
Description
Anti-Lassa virus/LASV Nucleoprotein Polyclonal Antibody (VK810034) is a rabbit polyclonal antibody detecting Nucleoprotein. Suitable for Lassa virus.
Species reactivityLassa virus (LASV)
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Lassa virus/LASV Nucleoprotein (Met1-Leu569).
Target EC:3.1.13.-, N, Nucleocapsid protein, Nucleoprotein, Protein N
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P13699
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Nucleoprotein is a ~62 kDa protein. Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation.

Note For research use only
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Formula
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Anti-Lassa virus/LASV Nucleoprotein Polyclonal Antibody

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