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Anti-Mouse CD150/SLAMF1 Polyclonal Antibody (MC275014)

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Overview
Catalog No.MC275014
Description
Anti-Mouse CD150/SLAMF1 Polyclonal Antibody (MC275014) is a rabbit polyclonal antibody detecting SLAMF1. Suitable for Mouse.
Species reactivityMouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse CD150/SLAMF1 (Asp31-Cys232).
Target CD150, CDw150, IPO-3, SLAM, SLAM family member 1, SLAMF1, Signaling lymphocytic activation molecule
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q9QUM4
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Signaling lymphocytic activation molecule (CD150/SLAMF1) is a ~38 kDa protein. Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.

1. Howie, D. et al. (2002) Blood 100, 2899-907. PMID: 12351401
2. Aversa, G. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 158, 4036-44. PMID: 9126961
3. Latour, S. et al. (2001) Nature immunology 2, 681-90. PMID: 11477403
4. Cannons, JL. et al. (2004) Immunity 21, 693-706. PMID: 15539155
5. Chen, R. et al. (2006) Molecular and cellular biology 26, 5559-68. PMID: 16847311
6. Wang, N. et al. (2004) The Journal of experimental medicine 199, 1255-64. PMID: 15123745
7. Yusuf, I. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 185, 190-202. PMID: 20525889
8. Wang, N. et al. (2006) American journal of respiratory cell and molecular biology 35, 206-10. PMID: 16528012
9. Griewank, K. et al. (2007) Immunity 27, 751-62. PMID: 18031695
Note For research use only
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Formula
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Anti-Mouse CD150/SLAMF1 Polyclonal Antibody

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