Anti-Mouse CD254/RANKL/TNFSF11 Recombinant Antibody (7C6) (MT439013)

Name: Anti-Mouse CD254/RANKL/TNFSF11 Recombinant Antibody (7C6)
Brand: abinScience
SKU: MT439013
Price: 196 USD
Availability: InStock

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1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

MT439013

Species reactivity

Mouse

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

7C6

Clonality

Monoclonal

Target

TNFSF11, OPGL, ODF, RANKL, TRANCE, Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor, Osteoprotegerin ligand, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, CD254

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O35235

RRID

Anti-Mouse CD254/RANKL/TNFSF11 Antibody (7C6) (abinScience Cat# MT439013, RRID:AB_3727125)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Tumor necrosis factor ligand superfamily member 11 (CD254/RANKL) is a ~35 kDa protein. Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. CD254 is the therapeutic target of denosumab (Prolia).

1. Linares, GR. et al. (2012) Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 27, 1553-65. PMID: 22437732

2. Mahoney, DJ. et al. (2008) The Journal of biological chemistry 283, 25952-62. PMID: 18586671

3. Tiedemann, K. et al. (2013) Journal of cell science 126, 4187-94. PMID: 24039232

4. Omata, Y. et al. (2016) PloS one 11, e0157992. PMID: 27336669

5. Kim, H. et al. (2013) Cell metabolism 17, 249-60. PMID: 23395171

6. Decker, CE. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 15654-9. PMID: 26644563

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Mouse CD254/RANKL/TNFSF11 Antibody (7C6)

References

Datasheet

Anti-Mouse CD254/RANKL/TNFSF11 Recombinant Antibody (7C6).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse CD254/RANKL/TNFSF11 Recombinant Antibody (7C6) (MT439013)

Overview

Images

References

Datasheet

SDS

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