InVivoMAb Anti-Mouse TRANCE/TNFSF11/RANK L Antibody (7C6) (MT439010)

Name: InVivoMAb Anti-Mouse TRANCE/TNFSF11/RANK L Antibody (7C6)
Brand: abinScience
SKU: MT439010
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	MT439010
Description	InVivoMAb Anti-Mouse CD254/RANKL Antibody (7C6) [7C6] (MT439010) is a mouse monoclonal antibody detecting Tumor necrosis factor ligand superfamily member 11 in ELISA, Neutralization. Suitable for Mouse.
Species reactivity	Mouse
Applications	ELISA, Neutralization
Host species	Mouse
Isotype	VHH-mFc
Clone ID	7C6
Clonality	Monoclonal
Target	Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor, ODF, Osteoprotegerin ligand, OPGL, Receptor activator of nuclear factor kappa-B ligand, RANKL, TNF-related activation-induced cytokine, TRANCE, CD254, Tumor necrosis factor ligand superfamily member 11, membrane form, Tumor necrosis factor ligand superfamily member 11, soluble form, Tnfsf11, Opgl, Rankl, Trance
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Associated products	pH 7.4 Dilution Buffer
Purification	Protein A/G purified from cell culture supernatant.
Accession	O35235
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Tumor necrosis factor ligand superfamily member 11 (CD254/RANKL) is a ~35 kDa protein. Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. CD254 is the therapeutic target of denosumab (Prolia). 1. Linares, GR. et al. (2012) Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 27, 1553-65. PMID: 22437732 2. Mahoney, DJ. et al. (2008) The Journal of biological chemistry 283, 25952-62. PMID: 18586671 3. Tiedemann, K. et al. (2013) Journal of cell science 126, 4187-94. PMID: 24039232 4. Omata, Y. et al. (2016) PloS one 11, e0157992. PMID: 27336669 5. Kim, H. et al. (2013) Cell metabolism 17, 249-60. PMID: 23395171 6. Decker, CE. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 15654-9. PMID: 26644563
Note	For research use only. Not suitable for clinical or therapeutic use.

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InVivoMAb Anti-Mouse TRANCE/TNFSF11/RANK L Antibody (7C6).pdf

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InVivoMAb Anti-Mouse TRANCE/TNFSF11/RANK L Antibody (7C6) (MT439010)

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