Anti-Mouse CD274/PD-L1/B7-H1 Recombinant Antibody (SAA0268) (MV974107)

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Catalog No.	MV974107
Description	Anti-Mouse CD274/PD-L1/B7-H1 Antibody (SAA0268) [SAA0268] (MV974107) is a rat monoclonal antibody detecting B7-H1 in ELISA, FCM. Suitable for Mouse. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Mouse
Applications	ELISA, FCM
Host species	Rat
Isotype	IgG1, kappa
Clone ID	SAA0268
Clonality	Monoclonal
Target	B7-H1, Programmed cell death 1 ligand 1, PDCD1 ligand 1, PDCD1L1, B7 homolog 1, PDCD1LG1, PDL1, hPD-L1, Programmed death ligand 1, B7H1, PD-L1, CD274
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9EP73
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Programmed cell death 1 ligand 1 (CD274/PD-L1) is a ~32 kDa protein. Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). CD274 is the therapeutic target of atezolizumab (Tecentriq) and durvalumab (Imfinzi). 1. Tamura, H. et al. (2001) Blood 97, 1809-16. PMID: 11238124 2. Freeman, GJ. et al. (2000) The Journal of experimental medicine 192, 1027-34. PMID: 11015443 3. Wang, S. et al. (2003) The Journal of experimental medicine 197, 1083-91. PMID: 12719480
Note	For research use only.

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Anti-Mouse CD274/PD-L1/B7-H1 Recombinant Antibody (SAA0268).pdf

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Anti-Mouse CD274/PD-L1/B7-H1 Recombinant Antibody (SAA0268) (MV974107)

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