Anti-Mouse ICOS Polyclonal Antibody (MV702014)

Name: Anti-Mouse ICOS Polyclonal Antibody
Brand: abinScience
SKU: MV702014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

MV702014

Species reactivity

Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse CD278/ICOS (Ser32-His130).

Target

Inducible T-cell costimulator (Activation-inducible lymphocyte immunomediatory molecule) (CD28 and CTLA-4-like protein) (CCLP) (CD28-related protein 1) (CRP-1) (CD antigen CD278)

Purification

Purified by antigen affinity column.

Accession

Q9WVS0

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Inducible T-cell costimulator (CD278/ICOS) is a ~22 kDa protein. Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response. Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Also acts as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection. Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling. In addition, activates PI3K signaling pathways independently of calcium flux.

1. Tafuri, A. et al. (2001) Nature 409, 105-9. PMID: 11343123

2. Ling, V. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 164, 1653-7. PMID: 10657606

3. Panneton, V. et al. (2023) Life science alliance 6. PMID: 36754569

4. Leconte, J. et al. (2016) Molecular immunology 79, 38-46. PMID: 27693916

5. Gigoux, M. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 20371-6. PMID: 19915142

6. McAdam, AJ. et al. (2001) Nature 409, 102-5. PMID: 11343122

Note

For research use only.

Images

References

Datasheet

Anti-Mouse ICOS Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-Mouse ICOS Polyclonal Antibody (MV702014)

Overview

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References

Datasheet

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