Mouse ICOS Recombinant Protein (C-Fc) (MV702011)

Name: Mouse ICOS Recombinant Protein (C-Fc)
Brand: abinScience
SKU: MV702011
Price: 298 USD
Availability: InStock

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Overview

Catalog No.	MV702011
Description	Recombinant Mouse CD278/ICOS Protein, C-Fc (MV702011) expressed in Mammalian Cells, spanning Glu21-Leu142. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian cells
Accession	Q9WVS0
Protein length	Glu21-Leu142
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	42.23 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	AILIM, Activation-inducible lymphocyte immunomediatory molecule, CD278, ICOS, Inducible T-cell costimulator
Background	Inducible T-cell costimulator is a ~22 kDa protein. Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response. Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Also acts as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection. Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling. In addition, activates PI3K signaling pathways independently of calcium flux. 1. Tafuri, A. et al. (2001) Nature 409, 105-9. PMID: 11343123 2. Ling, V. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 164, 1653-7. PMID: 10657606 3. Panneton, V. et al. (2023) Life science alliance 6. PMID: 36754569 4. Leconte, J. et al. (2016) Molecular immunology 79, 38-46. PMID: 27693916 5. Gigoux, M. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 20371-6. PMID: 19915142 6. McAdam, AJ. et al. (2001) Nature 409, 102-5. PMID: 11343122
Note	For research use only

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Datasheet

Mouse ICOS Recombinant Protein (C-Fc).pdf

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Mouse ICOS Recombinant Protein (C-Fc) (MV702011)

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