Anti-Mouse Transferrin R/TfR Recombinant Antibody (OX-26) (MY036207)

Name: Anti-Mouse Transferrin R/TfR Recombinant Antibody (OX-26)
Brand: abinScience
SKU: MY036207
Price: 196 USD
Availability: InStock

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Overview

Catalog No.	MY036207
Species reactivity	Human, Mouse, Rat
Applications	FCM, IF, IHC (P), IP, WB
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	OX-26
Clonality	Monoclonal
Target	Transferrin receptor protein 1, TR, TfR, TfR1, Trfr, CD71, Tfrc
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q62351
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Transferrin receptor protein 1 (CD71/TFRC) is a ~85 kDa protein. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Upon stimulation, positively regulates T and B cell proliferation through iron uptake. 1. Jabara, HH. et al. (2016) Nature genetics 48, 74-8. PMID: 26642240 2. Yang, J. et al. (2024) The Journal of clinical investigation 134. PMID: 38625739
Note	For research use only.