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Anti-Mouse CD71/TFRC Recombinant Antibody (R17217) (MY036107)

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Anti-Mouse CD71/TFRC Recombinant Antibody (R17217)

Anti-Mouse CD71/TFRC Recombinant Antibody (R17217)

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Overview

Catalog No.	MY036107
Description	Anti-Mouse CD71/TFRC Antibody (R17217) [R17217] (MY036107) is a mouse monoclonal antibody detecting CD71 in FCM. Suitable for Mouse. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Mouse
Applications	FCM
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	R17217
Clonality	Monoclonal
Target	Transferrin receptor protein 1, TR, TfR, TfR1, Trfr, CD71, Tfrc, R17 217.1.3, R17217, TIB-219
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q62351
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Transferrin receptor protein 1 (CD71/TFRC) is a ~85 kDa protein. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Upon stimulation, positively regulates T and B cell proliferation through iron uptake. 1. Jabara, HH. et al. (2016) Nature genetics 48, 74-8. PMID: 26642240 2. Yang, J. et al. (2024) The Journal of clinical investigation 134. PMID: 38625739
Note	For research use only.

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Bioactivity

Detects CD71/TFRC in indirect ELISAs.

References

Datasheet

Anti-Mouse CD71/TFRC Recombinant Antibody (R17217).pdf

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Formula

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Anti-Mouse CD71/TFRC Recombinant Antibody (R17217)