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Anti-Mouse IL24 Polyclonal Antibody (MC472014)

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Overview
Catalog No.MC472014
Description
Anti-Mouse IL24 Polyclonal Antibody (MC472014) is a rabbit polyclonal antibody detecting Il24. Suitable for Mouse.
Species reactivityMouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse IL24 (Gln27-Leu181).
Target IL-24, IL-4-induced secreted protein, Il24, Interleukin-24, MDA-7, Mda7, Melanoma differentiation-associated gene 7 protein, Th2-specific cytokine FISP
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q925S4
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Interleukin-24 (IL24) is a ~25 kDa protein. Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I interferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal.

1. Wang, J. et al. (2020) Cell death & disease 11, 17. PMID: 31907348
2. Davidson, S. et al. (2022) Science immunology 7, eabi6763. PMID: 35148201
Note For research use only
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Anti-Mouse IL24 Polyclonal Antibody

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