Anti-Optineurin Recombinant Antibody (6A7.1) (HP451013)

Name: Anti-Optineurin Recombinant Antibody (6A7.1)
Brand: abinScience
SKU: HP451013
Price: 110 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HP451013

Species reactivity

Human

Applications

IHC, WB

Host species

Mouse

Isotype

IgG2a

Clone ID

6A7.1

Clonality

Monoclonal

Target

NRP, TFIIIA-IntP, Huntingtin-interacting protein 7, HIP-7, Huntingtin yeast partner L, Transcription factor IIIA-interacting protein, NEMO-related protein, E3-14.7K-interacting protein, GLC1E, HIP7, HYPL, FIP-2, Huntingtin-interacting protein L, Optic neuropathy-inducing protein, OPTN, Optineurin, FIP2

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q96CV9

RRID

Anti-Optineurin Antibody (6A7.1) (abinScience Cat# HP451013, RRID:AB_3728971)
_x005F_x000D_

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Optineurin (OPTN) is a ~65 kDa protein. Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation. In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1.

1. Fifita, JA. et al. (2017) Amyotrophic lateral sclerosis & frontotemporal degeneration 18, 126-133. PMID: 27534431

2. Pourcelot, M. et al. (2016) BMC biology 14, 69. PMID: 27538435

3. Vaibhava, V. et al. (2012) Journal of cell science 125, 5026-39. PMID: 22854040

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Optineurin Antibody (6A7.1)

References

Datasheet

Anti-Optineurin Recombinant Antibody (6A7.1).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Optineurin Recombinant Antibody (6A7.1) (HP451013)

Overview

Images

References

Datasheet

SDS

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