Anti-Pannexin-1 Recombinant Antibody (N122A/17) (HP450013)

Name: Anti-Pannexin-1 Recombinant Antibody (N122A/17)
Brand: abinScience
SKU: HP450013
Price: 196 USD
Availability: InStock

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100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HP450013

Description

Anti-Pannexin-1 Recombinant Antibody (N122A/17) (HP450013) is a mouse monoclonal antibody detecting PANX1 in IHC, WB.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Applications

IHC, WB

Host species

Mouse

Clonality

Monoclonal

Isotype

IgG2a, kappa

Clone ID

N122A/17

Target

MRS1, Pannexin-1, PANX1

Endotoxin level

< 10 EU/mg as determined by LAL method.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

RRID

Anti-Pannexin-1 Antibody (N122A/17) (abinScience Cat# HP450013, RRID:AB_3728677)
_x005F_x000D_

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Pannexin-1 (PANX1) is a ~48 kDa protein. Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis. Forms anion-selective channels with relatively low conductance and an order of permeabilities: nitrate>iodide>chlroride>>aspartate=glutamate=gluconate. Can release ATP upon activation through phosphorylation or cleavage at C-terminus. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.

1. Bao, L. et al. (2004) FEBS letters 572, 65-8. PMID: 15304325

2. Vanden Abeele, F. et al. (2006) The Journal of cell biology 174, 535-46. PMID: 16908669

3. Bunse, S. et al. (2010) The Journal of biological chemistry 285, 38444-52. PMID: 20829356

4. Chekeni, FB. et al. (2010) Nature 467, 863-7. PMID: 20944749

5. Sang, Q. et al. (2019) Science translational medicine 11. PMID: 30918116

6. Medina, CB. et al. (2020) Nature 580, 130-135. PMID: 32238926

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Pannexin-1 Antibody (N122A/17)

References

Datasheet

Anti-Pannexin-1 Recombinant Antibody (N122A/17).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Pannexin-1 Recombinant Antibody (N122A/17) (HP450013)

Overview

Images

References

Datasheet

SDS