Anti-RABV G/Glycoprotein Antibody (SO57) (VK632113)

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1mg

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Overview
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Datasheet

Overview

Catalog No.

VK632113

Description

Anti-RABV G/Glycoprotein Antibody (SO57) [SO57] (VK632113) is a mouse monoclonal antibody detecting Glycoprotein in ELISA, WB, Neutralization. Suitable for Rabies virus.

Highlights

●Multi-Application — Validated across multiple applications.

Species reactivity

Rabies virus

Applications

ELISA, WB, Neutralization

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SO57

Clonality

Monoclonal

Target

Glycoprotein, G

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O92284

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Glycoprotein is a ~58 kDa protein. Attaches the virus to host cellular receptor, inducing endocytosis of the virion by using different host proteins including TFRC, GRM2 and ITGB1. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.

Note

For research use only

Images

SDS-PAGE

SDS-PAGE for Anti-RABV G/Glycoprotein Antibody (SO57)
Bioactivity

Detects recombinant Rabies virus/RABV G/Glycoprotein Protein (Catalog No: VK584021) in indirect ELISA