Anti-S1P/Sphingosine-1-phosphate Recombinant Antibody (SAA2035) (YP926013)

Name: Anti-S1P/Sphingosine-1-phosphate Recombinant Antibody (SAA2035)
Brand: abinScience
SKU: YP926013
Price: 110 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD): --

Spec:

20ug
50ug
100ug
1mg

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

YP926013

Description

Anti-S1P/Sphingosine-1-phosphate Recombinant Antibody (SAA2035) (YP926013) is a human monoclonal antibody detecting S1P/Sphingosine-1-phosphate in ELISA. Suitable for General.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.

Species reactivity

General

Applications

ELISA

Host species

Human

Clonality

Monoclonal

Isotype

IgG1, kappa

Clone ID

SAA2035

Target

S1P, Sphingosine-1-phosphateHuman Anti-S1P Recombinant Antibod SONEPCIZUMAB pleiotropic signaling lipid sphingosine-1-phosphate (S1P)A humanized monoclonal antibody directed against sphingosine 1-phosphate (S1P) with potential antiangiogenic and antineoplastic activities. Upon administration, sonepcizumab binds S1P, which may result in the inhibition of tumor angiogenesis. S1P is the extracellular ligand for the G protein-coupled lysophospholipid receptor EDG-1 (endothelial differentiation gene-1).

Endotoxin level

< 10 EU/mg as determined by LAL method.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

RRID

Anti-S1P/Sphingosine-1-phosphate Antibody (SAA2035) (abinScience Cat# YP926013, RRID:AB_3728966)
_x005F_x000D_

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Adenosine 3', 5'-cyclic monophosphate (cAMP) is a key second messenger molecule in intracellular signal transduction. Monitoring cAMP levels is one of the most common ways to screen for agonists and antagonists of G protein–coupled receptors(GPCRs). Bioyeargene cAMP ELISA Kit is based on the competition between HRP-labeled cAMP and free cAMP for fixed amounts of mouse monoclonal anti-cAMP antibody(cAMP MAb) binding sites. Because the concentration of the HRP-labeled cAMP is held constant while the concentration of cAMP varies, the amount of HRP-labeled cAMP that is able to bind to the cAMP MAb will be inversely proportional to the concentration of cAMP in the well. This antigen-antibody complex binds to the goat anti-mouse IgG that has been previously attached to the well. The plate is washed to remove any unbound reagents and then developed. The ELISA typically displays an IC50(50% B/B0) of approximately 12 pmol/mL and a detection limit of approximately 0.15 pmol/mL.
• Sphingosine 1-phosphate: Lipid signaling in pathology and therapy., PMID:31624181
• Sphingosine-1-phosphate (S1P) in ovarian physiology and disease., PMID:31455516
• Sphingosine-1-phosphate (S1P) receptors: Promising drug targets for treating bone-related diseases., PMID:32155312
• Pancreatic Acinar Cells-Derived Sphingosine-1-Phosphate Contributes to Fibrosis of Chronic Pancreatitis via Inducing Autophagy and Activation of Pancreatic Stellate Cells., PMID:37634735
• Significance of sphingosine-1-phosphate in cardiovascular physiology and pathology., PMID:32278039
• Sphingosine 1-Phosphate (S1P)/ S1P Receptor Signaling and Mechanotransduction: Implications for Intrinsic Tissue Repair/Regeneration., PMID:31703256
• Sphingosine 1-phosphate (S1P) receptor modulators as an induction and maintenance therapy for ulcerative colitis: a systematic review and meta-analysis of randomized controlled trials., PMID:38153524
• S1P (Sphingosine-1-Phosphate)-Induced Vasodilation in Human Resistance Arterioles During Health and Disease., PMID:36070401
• Sphingosine 1-phosphate (S1P) signalling: Role in bone biology and potential therapeutic target for bone repair., PMID:28855094
• Sphingosine 1-phosphate signalling., PMID:24346695

Note

For research use only.

Isotype Control

Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21) (MV080207)

Images

SDS-PAGE

SDS-PAGE for Anti-S1P/Sphingosine-1-phosphate Antibody (SAA2035)

References

Datasheet

Anti-S1P/Sphingosine-1-phosphate Recombinant Antibody (SAA2035).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-S1P/Sphingosine-1-phosphate Recombinant Antibody (SAA2035) (YP926013)

Overview

Images

References

Datasheet

SDS