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Anti-SFN Polyclonal Antibody (HB182014)

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Overview
Catalog No.HB182014
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human SFN (Met1-Ser248).
Target Stratifin, Epithelial cell marker protein 1, HME1, 14-3-3 protein sigma, SFN
Purification Purified by antigen affinity column.
Accession P31947
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

14-3-3 protein sigma (SFN) is a ~27 kDa protein. Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response. Also acts as a TP53/p53-regulated inhibitor of G2/M progression.

1. Wilker, EW. et al. (2005) The Journal of biological chemistry 280, 18891-8. PMID: 15731107
2. Rose, R. et al. (2012) Journal of structural biology 180, 65-72. PMID: 22634725
3. Stevers, LM. et al. (2017) The Biochemical journal 474, 1273-1287. PMID: 28202711
4. Fisch, D. et al. (2023) Science (New York, N.Y.) 382, eadg2253. PMID: 37797010
7. Rietscher, K. et al. (2018) Journal of cell science 131. PMID: 29678907
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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V₁ (Stock Vol.)
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C₂ (Working Conc.)
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Anti-SFN Polyclonal Antibody

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