Anti-sLea/CA19-9 Recombinant Antibody (5B1) (HP481033)

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sLea/CA19-9 is a protein, also known as HuMab-5B1, MVT-5873. Sialyl Lewis A mediates adhesion of human colon, pancreas, and gastric cancer cells to E-selectin-expressing endothelial cells, with complete abolition of this adhesion when Sialyl Lewis A expression is suppressed via antisense FT III cDNA transfection [1]. Sialyl Lewis A mediates adhesion of human urinary bladder cancer Hu 1703He cells to E-selectin-expressing CHO cells [1]. Sialyl Lewis A expression is required for the tumorigenicity of human squamous lung cancer cells in athymic nu/nu nude mice [1]. Sialyl Lewis A mediates nearly exclusive ELAM-1-dependent adhesion of Capan2, 2102Ep, QG90, Colo201, WiDr, and SW1116 human epithelial cancer cell lines to rIL1β-activated HUVECs [2]. Sialyl Lewis A is strongly expressed on the surface of Capan2, 2102Ep, QG90, Colo201, WiDr, and SW1116 human epithelial cancer cell lines, but is not detected on any of the 12 tested human leukemia cell lines [2]. Sialyl Lewis A does not contribute to the adhesion of any of the 12 tested human leukemia cell lines to rIL1β-activated HUVECs [2].