

| Catalog No. | JN856013 | ||||
|---|---|---|---|---|---|
| Species reactivity | Staphylococcus aureus | ||||
| Applications | ELISA | ||||
| Host species | Mouse | ||||
| Isotype | IgG2a | ||||
| Clone ID | SAA1453 | ||||
| Clonality | Monoclonal | ||||
| Target | spa, Immunoglobulin G-binding protein A, Staphylococcal protein A | ||||
| Purity | >95% as determined by SDS-PAGE. | ||||
| Purification | Protein A/G purified from cell culture supernatant. | ||||
| Accession | P38507 | ||||
| RRID | Anti-Staphylococcus aureus Protein A/SPA Antibody (SAA1453) (abinScience Cat# JN856013, RRID:AB_3727082) |
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| Form | Liquid | ||||
| Storage buffer | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| Background | Immunoglobulin G-binding protein A (SPA) is a ~55 kDa protein. Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins. In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region. In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production. Inhibits osteogenesis by preventing osteoblast proliferation and expression of alkaline phosphatase, type I collagen, osteopontin and osteocalcin. | ||||
| Note | For research use only. |

SDS-PAGE for Anti-Staphylococcus aureus Protein A/SPA Antibody (SAA1453)




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