Anti-THBS1 Polyclonal Antibody (HY205014)

Name: Anti-THBS1 Polyclonal Antibody
Brand: abinScience
SKU: HY205014
Price: 168 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

50ug
100ug

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HY205014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human THBS1 (Ser24-Thr221).

Target

TSP, THBS1, TSP1, Thrombospondin-1, Glycoprotein G

Purification

Purified by antigen affinity column.

Accession

P07996

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Thrombospondin-1 (THBS1) is a ~129 kDa protein. Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Multifunctional, involved in inflammation, angiogenesis, wound healing, reactive oxygen species (ROS) signaling, nitrous oxide (NO) signaling, apoptosis, senescence, aging, cellular self-renewal, stemness, and cardiovascular and metabolic homeostasis. Negatively modulates dendritic cell activation and cytokine release, as part of an autocrine feedback loop, contributing to the resolution of inflammation and immune homeostasis. Ligand for receptor CD47. Modulates nitrous oxide (NO) signaling via CD47, hence playing a role as a pressor agent, supporting blood pressure.

1. Kvansakul, M. et al. (2004) The EMBO journal 23, 1223-33. PMID: 15014436

2. Adams, JC. et al. (2008) Journal of cell science 121, 784-95. PMID: 18285447

3. Lawler, J. et al. (1986) The Journal of cell biology 103, 1635-48. PMID: 2430973

4. Lahav, J. et al. (1984) European journal of biochemistry 145, 151-6. PMID: 6489349

5. Jiménez, B. et al. (2000) Nature medicine 6, 41-8. PMID: 10613822

6. Simantov, R. et al. (2001) The Journal of clinical investigation 107, 45-52. PMID: 11134179

7. Asch, AS. et al. (1992) Biochemical and biophysical research communications 182, 1208-17. PMID: 1371676

8. Doyen, V. et al. (2003) The Journal of experimental medicine 198, 1277-83. PMID: 14568985

9. Yao, M. et al. (2014) Journal of the American Society of Nephrology : JASN 25, 1171-86. PMID: 24511121

10. Meijles, DN. et al. (2017) Science signaling 10. PMID: 29042481

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-THBS1 polyclonal antibody at 1ug/mL on recombinant THBS1 (Catalog No. HY205012).

References

Datasheet

Anti-THBS1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-THBS1 Polyclonal Antibody (HY205014)

Overview

Images

References

Datasheet

SDS

Quick access

Contact Us