Anti-Tupaia chinensis LAMP-1/CD107a Polyclonal Antibody (ZY332014)

Name: Anti-Tupaia chinensis LAMP-1/CD107a Polyclonal Antibody
Brand: abinScience
SKU: ZY332014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

ZY332014

Description

Anti-Tupaia chinensis CD107a/LAMP1 Polyclonal Antibody (ZY332014) is a rabbit polyclonal antibody detecting lysosome-associated membrane glycoprotein 1; LAMP1 in ELISA, IHC, WB. Suitable for Tupaia chinensis.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Tupaia chinensis (Chinese tree shrew)

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant tupaia chinensis CD107a/LAMP1 (Met136-Met484).

Target

lysosome-associated membrane glycoprotein 1; LAMP1

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Lysosome-associated membrane glycoprotein 1 (CD107a/LAMP1) is a ~44 kDa protein. Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content.

1. Zhang, J. et al. (2023) Molecular cell 83, 2524-2539.e7. PMID: 37390818

2. Peters, PJ. et al. (1991) The Journal of experimental medicine 173, 1099-109. PMID: 2022921

3. Krzewski, K. et al. (2013) Blood 121, 4672-83. PMID: 23632890

4. Cohnen, A. et al. (2013) Blood 122, 1411-8. PMID: 23847195

5. Sawada, R. et al. (1993) The Journal of biological chemistry 268, 12675-81. PMID: 7685349

Note

For research use only

Images

References

Datasheet

Anti-Tupaia chinensis LAMP-1/CD107a Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Tupaia chinensis LAMP-1/CD107a Polyclonal Antibody (ZY332014)

Overview

Images

References

Datasheet

SDS