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Anti-UBA7 Polyclonal Antibody (HW373014)

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Overview
Catalog No.HW373014
Description
Anti-UBA7 Polyclonal Antibody (HW373014) is a rabbit polyclonal antibody detecting UBA7 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human UBA7 (Lys429-Val488).
Target D8, Ubiquitin-activating enzyme 7, UBE1L, UBA7, Ubiquitin-like modifier-activating enzyme 7, UBE2, Ubiquitin-activating enzyme E1 homolog
Purification Purified by antigen affinity column.
Accession P41226
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Ubiquitin-like modifier-activating enzyme 7 (UBA7) is a ~111 kDa protein. E1-activating enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of ISG15 to additional interferon stimulated proteins (ISGs) as well as other cellular proteins such as P53 in a process termed protein ISGylation. Plays an essential role in antiviral immunity together with ISG15 by restricting the replication of many viruses including rabies virus, influenza virus, sindbis virus, rotavirus or human cytomegalovirus. For example, ISG15 modification of influenza A protein NS1 disrupts the association of the NS1 with importin-alpha leading to NS1 nuclear import inhibition. ISGylation of human cytomegalovirs protein UL26 regulates its stability and inhibits its activities to suppress NF-kappa-B signaling.

1. Park, JH. et al. (2016) Nature communications 7, 12513. PMID: 27545325
2. Lenschow, DJ. et al. (2005) Journal of virology 79, 13974-83. PMID: 16254333
3. Giannakopoulos, NV. et al. (2009) Journal of virology 83, 1602-10. PMID: 19073728
4. Zhao, P. et al. (2017) Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 56, 44-53. PMID: 29056542
5. Lee, MK. et al. (2018) Journal of virology 92. PMID: 29743376
6. Sarkar, R. et al. (2023) Cellular signalling 112, 110891. PMID: 37722521
7. Zhao, C. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 2253-8. PMID: 20133869
8. Kim, YJ. et al. (2016) PLoS pathogens 12, e1005850. PMID: 27564865
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Volume
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g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-UBA7 Polyclonal Antibody

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