Anti-WDR5 Polyclonal Antibody (HX013014)

Name: Anti-WDR5 Polyclonal Antibody
Brand: abinScience
SKU: HX013014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HX013014

Description

Anti-WDR5 Polyclonal Antibody (HX013014) is a rabbit polyclonal antibody detecting WDR5 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Xenopus tropicalis.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human WDR5 (Met1-Lys120).

Target

WDR5, BMP2-induced 3-kb gene protein, WD repeat-containing protein 5, BIG3

Purification

Purified by antigen affinity column.

Accession

P61964

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

WD repeat-containing protein 5 (WDR5) is a ~36 kDa protein. Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues.

1. Han, Z. et al. (2006) Molecular cell 22, 137-44. PMID: 16600877

2. Couture, JF. et al. (2006) Nature structural & molecular biology 13, 698-703. PMID: 16829960

3. Guelman, S. et al. (2009) Molecular and cellular biology 29, 1176-88. PMID: 19103755

4. Garapaty, S. et al. (2009) The Journal of biological chemistry 284, 7542-52. PMID: 19131338

5. Patel, A. et al. (2009) The Journal of biological chemistry 284, 24242-56. PMID: 19556245

6. Cai, Y. et al. (2010) The Journal of biological chemistry 285, 4268-72. PMID: 20018852

7. Song, JJ. et al. (2008) The Journal of biological chemistry 283, 35258-64. PMID: 18840606

8. Avdic, V. et al. (2011) Structure (London, England : 1993) 19, 101-8. PMID: 21220120

9. Zhang, P. et al. (2012) Nucleic acids research 40, 4237-46. PMID: 22266653

Note

For research use only.

Images

References

Datasheet

Anti-WDR5 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-WDR5 Polyclonal Antibody (HX013014)

Overview

Images

References

Datasheet

SDS

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