HEK293T SARS-CoV-2 Nucleoprotein (N) Stable Cell Line (VK805818)

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Overview

Catalog No.	VK805818
Description	HEK293T SARS-CoV-2 Nucleoprotein (N) Stable Cell Line (VK805818) is a stable cell line expressing SARS-CoV-2 Nucleoprotein (N). Engineered for consistent, high-level target expression in research applications. Highlights ●Stable Expression — Engineered for consistent, high-level target expression.
Accession	P0DTC9
Applications	FCM
Species	Viral (SARS-CoV-2)
Host species	HEK293T
Target	SARS-CoV-2 Nucleoprotein (N)
Properties	Growth Properties: Adherent; Selection Marker: Puromycin (1 μg/mL)
Stability and Storage	Frozen in liquid nitrogen.
Specifications	1 vial contains at least 2×10^6 cells in 1 mL Freeze Medium
Background	Nucleoprotein (SARS-CoV-2 Nucleoprotein (N)) is a ~45 kDa protein. Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Attenuates the stress granules formation by reducing host G3BP1 access to host mRNAs under stress conditions. 1. Dinesh, DC. et al. (2020) PLoS pathogens 16, e1009100. PMID: 33264373 2. Nabeel-Shah, S. et al. (2022) iScience 25, 103562. PMID: 34901782 3. Dolliver, SM. et al. (2022) PLoS pathogens 18, e1011041. PMID: 36534661