InVivo Plus Anti-Mouse IFN-alpha/beta R1 Antibody(MAR1-5A3) (MB823109)

Name: InVivo Plus Anti-Mouse IFN-alpha/beta R1 Antibody(MAR1-5A3)
Brand: abinScience
SKU: MB823109
Price: 128 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

MB823109

Description

InVivo Plus Anti-Mouse IFNAR1 Antibody (MAR1-5A3) [MAR1-5A3] (MB823109) is a rat monoclonal antibody detecting Interferon alpha/beta receptor 1 in in vivo IFNAR-1 blockade, in vitro IFNAR-1 blockade, WB. Suitable for Mouse.

Highlights

●Multi-Application — Validated across multiple applications.

Species reactivity

Mouse

Applications

in vivo IFNAR-1 blockade, in vitro IFNAR-1 blockade, WB

Host species

Mouse

Isotype

IgG1, kappa

Clone ID

MAR1-5A3

Clonality

Monoclonal

Target

Interferon alpha/beta receptor 1, Cytokine receptor family 2 member 1, Cytokine receptor class-II member 1, CRF2-1, IFN-R-1, IFNAR1, IFNAR, IFN-alpha/beta receptor 1, Type I interferon receptor 1

Endotoxin level

<1 EU/mg

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P33896

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Interferon alpha/beta receptor 1 (IFNAR1) is a ~65 kDa protein. Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

1. Kumar, KG. et al. (2003) The EMBO journal 22, 5480-90. PMID: 14532120

2. Uzé, G. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 4774-8. PMID: 1533935

3. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985

4. de Weerd, NA. et al. (2013) Nature immunology 14, 901-7. PMID: 23872679

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for InVivo Plus Anti-Mouse IFNAR1 Antibody (MAR1-5A3)

References

Datasheet

InVivo Plus Anti-Mouse IFN-alpha/beta R1 Antibody(MAR1-5A3).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

InVivo Plus Anti-Mouse IFN-alpha/beta R1 Antibody(MAR1-5A3) (MB823109)

Overview

Images

References

Datasheet

SDS

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