InVivoMAb Anti-Human Thrombopoietin R/Tpo R Antibody (3D9) (HW601010)

Name: InVivoMAb Anti-Human Thrombopoietin R/Tpo R Antibody (3D9)
Brand: abinScience
SKU: HW601010
Price: 370 USD
Availability: InStock

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100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HW601010

Description

InVivoMAb Anti-Human CD110/TPOR Antibody (3D9) [3D9] (HW601010) is a human monoclonal antibody detecting TPO-R in Agonist, ELISA. Suitable for Human.

Species reactivity

Human

Applications

Agonist, ELISA

Host species

Human

Isotype

IgG1

Clone ID

3D9

Clonality

Monoclonal

Target

TPO-R, TPOR, Thrombopoietin receptor, MPL, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, CD110

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Associated products

pH 7.4 Dilution Buffer

Purification

Protein A/G purified from cell culture supernatant.

Accession

P40238

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Thrombopoietin receptor (CD110/TPOR) is a ~71 kDa protein. Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K. In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production.

1. Royer, Y. et al. (2005) The Journal of biological chemistry 280, 27251-61. PMID: 15899890

2. Tsutsumi, N. et al. (2023) Cell 186, 4189-4203.e22. PMID: 37633268

Note

For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Human CD110/TPOR Antibody (3D9)

References

Datasheet

InVivoMAb Anti-Human Thrombopoietin R/Tpo R Antibody (3D9).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

InVivoMAb Anti-Human Thrombopoietin R/Tpo R Antibody (3D9) (HW601010)

Overview

Images

References

Datasheet

SDS

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