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InVivoMAb Anti-Human IL-11 Antibody (X203) (HB978010)

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InVivoMAb Anti-Human IL-11 Antibody (X203)

InVivoMAb Anti-Human IL-11 Antibody (X203)

InVivoMAb Anti-Human IL-11 Antibody (X203)

InVivoMAb Anti-Human IL-11 Antibody (X203)

InVivoMAb Anti-Human IL-11 Antibody (X203)

InVivoMAb Anti-Human IL-11 Antibody (X203)

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Spec:

100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.	HB978010
Description	InVivoMAb Anti-Human IL11 Antibody (X203) [X203] (HB978010) is a mouse monoclonal antibody detecting Interleukin-11 in FuncS. Suitable for Human.
Species reactivity	Human
Applications	FuncS
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	X203
Clonality	Monoclonal
Target	Interleukin-11, IL-11, Adipogenesis inhibitory factor, AGIF, Oprelvekin, IL11
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P20809
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. 1. Paul, SR. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 7512-6. PMID: 2145578 2. Harmegnies, D. et al. (2003) The Biochemical journal 375, 23-32. PMID: 12919066 3. Lamertz, L. et al. (2018) Science signaling 11. PMID: 30279168
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Human IL11 Antibody (X203)
Bioactivity

Detects recombinant human IL11-SUMO (Catalog No: HB978022) in indirect ELISA
Western blot

Western blot analysis was performed using anti-IL11 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human IL11 (Catalog No: HB978022)
Lane 2: negative control

References

Datasheet

InVivoMAb Anti-Human IL-11 Antibody (X203).pdf

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InVivoMAb Anti-Human IL-11 Antibody (X203)