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InVivoMAb Anti-Mouse SIRP alpha/CD172a Antibody (Ab25) (MX892030)

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InVivoMAb Anti-Mouse SIRP alpha/CD172a Antibody (Ab25)

InVivoMAb Anti-Mouse SIRP alpha/CD172a Antibody (Ab25)

InVivoMAb Anti-Mouse SIRP alpha/CD172a Antibody (Ab25)

InVivoMAb Anti-Mouse SIRP alpha/CD172a Antibody (Ab25)

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Spec:

100ug
1mg

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Datasheet
SDS

Overview

Catalog No.	MX892030
Description	InVivoMAb Anti-Mouse SIRPA Antibody (Ab25) [Ab25] (MX892030) is a mouse monoclonal antibody detecting Tyrosine-protein phosphatase non-receptor type substrate 1 in ELISA, Neutralization. Suitable for Mouse.
Species reactivity	Mouse
Applications	ELISA, Neutralization
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	Ab25
Clonality	Monoclonal
Target	Tyrosine-protein phosphatase non-receptor type substrate 1, SHP substrate 1, SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Bit, CD172 antigen-like family member A, Inhibitory receptor SHPS-1, MyD-1 antigen, Signal-regulatory protein alpha-1, Sirp-alpha-1, mSIRP-alpha1, p84, CD172a, Sirpa, Bit, Myd1, Ptpns1, Shps1, Sirp
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P97797
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Tyrosine-protein phosphatase non-receptor type substrate 1 (CD172a/SIRPA) is a ~56 kDa protein. Immunoglobulin-like cell surface receptor for CD47. Acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. 1. Nakaishi, A. et al. (2008) Journal of molecular biology 375, 650-60. PMID: 18045614 2. Sarute, N. et al. (2019) PLoS biology 17, e3000137. PMID: 30726215
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Mouse SIRPA Antibody (Ab25)
Bioactivity

Detects recombinant mouse CD172a/SIRPA (Catalog No: MX892011) in indirect ELISA

References

Datasheet

InVivoMAb Anti-Mouse SIRP alpha/CD172a Antibody (Ab25).pdf

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InVivoMAb Anti-Mouse SIRP alpha/CD172a Antibody (Ab25)