InVivoMAb Anti-Poliovirus Capsid protein VP1 Antibody (C3) (VK557010)

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100ug
1mg

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Overview

Catalog No.	VK557010
Description	InVivoMAb Anti-Poliovirus Capsid protein VP1 (C3) [C3] (VK557010) is a human monoclonal antibody detecting Genome polyprotein in ELISA, Neutralization.
Species reactivity	Poliovirus type 1 (strain Mahoney)
Applications	ELISA, Neutralization
Host species	Human
Isotype	IgG4, kappa
Clone ID	C3
Clonality	Monoclonal
Target	Genome polyprotein, Capsid protein VP1, Virion protein 1
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P03300
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Genome polyprotein (Capsid protein VP1) is a ~246 kDa protein. Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. Capsid protein VP1 mainly forms the vertices of the capsid. Capsid protein VP1 interacts with host cell receptor PVR to provide virion attachment to target host epithelial cells. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis in Hela cells and through caveolin-mediated endocytosis in brain microvascular endothelial cells. 1. Hogle, JM. et al. (1985) Science (New York, N.Y.) 229, 1358-65. PMID: 2994218 2. Strauss, M. et al. (2013) Journal of virology 87, 3903-14. PMID: 23365424 3. Strauss, M. et al. (2015) Journal of virology 89, 4143-57. PMID: 25631086 4. Brandenburg, B. et al. (2007) PLoS biology 5, e183. PMID: 17622193 5. Coyne, CB. et al. (2007) The EMBO journal 26, 4016-28. PMID: 17717529 6. Bergelson, JM. (2008) Trends in microbiology 16, 44-7. PMID: 18191571
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Poliovirus Capsid protein VP1 (C3).

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Datasheet

InVivoMAb Anti-Poliovirus Capsid protein VP1 Antibody (C3).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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C₁ × V₁ = C₂ × V₂

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InVivoMAb Anti-Poliovirus Capsid protein VP1 Antibody (C3) (VK557010)

Overview

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References

Datasheet

SDS

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