Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names
Autoprotease p20, Capsid protein C, Cysteine protease NS2, E(rns) glycoprotein, EC:2.7.7.48, EC:3.4.21.113, EC:3.4.22.-, EC:3.6.1.15, EC:3.6.4.13, EC:4.6.1.19, Envelope glycoprotein E1, Envelope glycoprotein E2, Genome polyprotein, N-pro, N-terminal protease, NS4A, NS4B, NS5A, NS5B, Non-structural protein 2, Non-structural protein 2-3, Non-structural protein 3, Non-structural protein 4A, Non-structural protein 4B, Non-structural protein 5A, RNA-directed RNA polymerase, Serine protease NS3, Viroporin p7, gp33, gp44/48, gp55, p10, p14, p30, p54, p58, p75, p80
Background
Genome polyprotein is a ~449 kDa protein. Leader cysteine autoprotease that cleaves itself from the nascent polyprotein during translation of the viral mRNA. Once released, plays a role in the inhibition of host innate immune response by interacting with host IRF3 and inducing its proteasomal degradation.
1. Chen, Z. et al. (2007) Virology 366, 277-92. PMID: 17531282
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