Human CD322/JAM2 Recombinant Protein (C-Fc) (HX993021)

Name: Human CD322/JAM2 Recombinant Protein (C-Fc)
Brand: abinScience
SKU: HX993021
Price: 298 USD
Availability: InStock

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Overview

Catalog No.	HX993021
Description	Recombinant Human CD322/JAM2 Protein, C-Fc (HX993021) expressed in Mammalian Cells, spanning Met1-Asn236. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian cells
Accession	P57087
Protein length	Met1-Asn236
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	52.98 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	C21orf43, CD322, JAM-2, JAM-B, JAM2, Junctional adhesion molecule 2, Junctional adhesion molecule B, VE-JAM, VEJAM, Vascular endothelial junction-associated molecule
Background	Junctional adhesion molecule B is a ~33 kDa protein. Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium. Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1. 1. Arrate, MP. et al. (2001) The Journal of biological chemistry 276, 45826-32. PMID: 11590146 2. Liang, TW. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 1618-26. PMID: 11823489 3. Arcangeli, ML. et al. (2014) Stem cells (Dayton, Ohio) 32, 1043-54. PMID: 24357068 4. Johnson-Léger, CA. et al. (2002) Blood 100, 2479-86. PMID: 12239159 5. Cunningham, SA. et al. (2002) The Journal of biological chemistry 277, 27589-92. PMID: 12070135
Note	For research use only

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Datasheet

Human CD322/JAM2 Recombinant Protein (C-Fc).pdf

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Human CD322/JAM2 Recombinant Protein (C-Fc) (HX993021)

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