Human CX3CL1/Fractalkine Recombinant Protein (N-His-KSI) (HX143022)

Name: Human CX3CL1/Fractalkine Recombinant Protein (N-His-KSI)
Brand: abinScience
SKU: HX143022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HX143022
Description	Recombinant Human CX3CL1/Fractalkine Protein, N-His-KSI (HX143022) expressed in E. coli, spanning Asp90-Gln245. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P78423
Protein length	Asp90-Gln245
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	31.59 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	C-X3-C motif chemokine 1, CX3C membrane-anchored chemokine, CX3CL1, FKN, Fractalkine, NTT, Neurotactin, Processed fractalkine, SCYD1, Small-inducible cytokine D1
Background	Fractalkine is a ~42 kDa protein. Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. Regulates leukocyte adhesion and migration processes at the endothelium. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. 1. Nishimura, M. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 6173-80. PMID: 12055230 2. Xue, X. et al. (2011) PLoS pathogens 7, e1002162. PMID: 21829356 3. Fujita, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 5809-19. PMID: 23125415 4. Fong, AM. et al. (1998) The Journal of experimental medicine 188, 1413-9. PMID: 9782118 5. Mizoue, LS. et al. (1999) Biochemistry 38, 1402-14. PMID: 9931005 6. Bazan, JF. et al. (1997) Nature 385, 640-4. PMID: 9024663 7. Pan, Y. et al. (1997) Nature 387, 611-7. PMID: 9177350 8. Fujita, M. et al. (2014) PloS one 9, e96372. PMID: 24789099
Note	For research use only

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Human CX3CL1/Fractalkine Recombinant Protein (N-His-KSI).pdf

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Human CX3CL1/Fractalkine Recombinant Protein (N-His-KSI) (HX143022)

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